Game Creation
Scratch
An educational game creation tool from MIT
Scratch is a new programming language that makes it easy to create your own interactive stories, animations, games, music, and art -- and share your creations on the web.
Scratch is designed to help young people (ages 8 and up) develop 21st century learning skills. As they create Scratch projects, young people learn important mathematical and computational ideas, while also gaining a deeper understanding of the process of design.
Scratch is available free of charge, go to Download.
Currently available for Mac OSX and Windows ( system requirements)
To find more about the ideas underlying Scratch, visit the page for Educators.
Gamestar Mechanic
Gamestar Mechanic was developed through a unique collaboration between Gamelab and the Games and Professional Practice Simulations (GAPPS) group at the University of Wisconsin-Madison. Funded as part of the MacArthur Foundation’s Digital Media and Learning Initiative the project supports many 21st century skills and aims to give young people a platform to express their ideas through the making and sharing of games.
http://www.gamestarmechanic.com/
Solve Puzzles for Science
Trying to understand Protein Folding?
Then this game might just be for you.
Foldit is a revolutionary new computer game enabling you to contribute to important scientific research.
GameSalad.com 
An online community created to support amateur and professional game creators to connect, gather resources, exchange ideas, post their portfolio, play member created games and connect games to social networking platforms.
GameSalad Creator for Mac 
An intuitive development platform that democratizes game design by enabling non-programmers to create original, sophisticated games. Through a user-friendly interface, game designers can access complex algorithms necessary for implementing professional-level artificial intelligence and game play, without programming knowledge.
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